.Pharmacolibrary.Drugs.V_Various.V04C_OtherDiagnosticAgents.V04CD01_Metyrapone.Metyrapone .Pharmacolibrary.Drugs.V_Various.V04C_OtherDiagnosticAgents.V04CD01_Metyrapone.Metyrapone| name: | Metyrapone |
| ATC code: | V04CD01 | route: | oral |
| n-compartments | 1 |
Metyrapone is an inhibitor of adrenal steroidogenesis by blocking 11-β-hydroxylase, leading to decreased cortisol synthesis. It is primarily used as a diagnostic agent for hypothalamic-pituitary-adrenal (HPA) axis disorders and, less commonly, as a treatment for Cushing's syndrome. It has been used clinically for many years and remains available as a diagnostic drug.
Pharmacokinetic parameters estimated for healthy adults following oral administration; no comprehensive human population PK models published in indexed literature.
Spitz, IM, et al., & Wade, CE (1993). The divergent effect of RU 486 on adrenal function in the dog is related to differences in its pharmacokinetics. Acta endocrinologica 128(5) 459–465. DOI:10.1530/acta.0.1280459 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8391196