modelAminohippuricAcid
Extends from Pharmacolibrary.Drugs.ATC.V.V04CH30.
Information
| name: | AminohippuricAcid | |
| ATC code: | V04CH30 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 0.21 | L |
| clearance: | 600 | ml/min |
| other parameters in model implementation | ||
Aminohippuric acid (also known as para-aminohippuric acid, PAH) is an organic acid historically used as a diagnostic agent to measure renal plasma flow and renal function. It is not approved or used today as a therapeutic drug.
Pharmacokinetics
Adults, healthy volunteers. Classic renal clearance and renal plasma flow tests, intravenous bolus administration.
References
Dhondt, L, et al., & Devreese, M (2020). Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model. Frontiers in pharmacology 11 607101–None. DOI:10.3389/fphar.2020.607101 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33574754
Dubinsky, S, et al., & Edginton, A (2022). Determining the Effects of Chronic Kidney Disease on Organic Anion Transporter1/3 Activity Through Physiologically Based Pharmacokinetic Modeling. Clinical pharmacokinetics 61(7) 997–1012. DOI:10.1007/s40262-022-01121-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35508593
Dhondt, L, et al., & Devreese, M (2021). The Development of a Juvenile Porcine Augmented Renal Clearance Model Through Continuous Infusion of Lipopolysaccharides: An Exploratory Study. Frontiers in veterinary science 8 639771–None. DOI:10.3389/fvets.2021.639771 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33996970
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)