.Pharmacolibrary.Drugs.V_Various.V04C_OtherDiagnosticAgents.V04CH30_AminohippuricAcid.AminohippuricAcid

Information

Aminohippuric acid (also known as para-aminohippuric acid, PAH) is an organic acid historically used as a diagnostic agent to measure renal plasma flow and renal function. It is not approved or used today as a therapeutic drug.

Pharmacokinetics

Adults, healthy volunteers. Classic renal clearance and renal plasma flow tests, intravenous bolus administration.

References

1. Dhondt, L, et al., & Devreese, M (2020). Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model. Frontiers in pharmacology 11 607101–None. DOI:10.3389/fphar.2020.607101 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33574754

2. Dubinsky, S, et al., & Edginton, A (2022). Determining the Effects of Chronic Kidney Disease on Organic Anion Transporter1/3 Activity Through Physiologically Based Pharmacokinetic Modeling. Clinical pharmacokinetics 61(7) 997–1012. DOI:10.1007/s40262-022-01121-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35508593

3. Dhondt, L, et al., & Devreese, M (2021). The Development of a Juvenile Porcine Augmented Renal Clearance Model Through Continuous Infusion of Lipopolysaccharides: An Exploratory Study. Frontiers in veterinary science 8 639771–None. DOI:10.3389/fvets.2021.639771 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33996970

Revisions

• 06/2025 initial generated model