modelMethacholine
Extends from Pharmacolibrary.Drugs.ATC.V.V04CX03.
Information
| name: | Methacholine | |
| ATC code: | V04CX03 | route: | inhalation |
| compartments: | 1 | |
| dosage: | 200 | mg |
| volume of distribution: | 0.2 | L |
| clearance: | 100 | L/h/kg |
| other parameters in model implementation | ||
Methacholine is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist. It is primarily used in the diagnosis of bronchial hyperreactivity (asthma) in the form of a methacholine challenge test. Methacholine is not used as a therapeutic drug; its approved use is in diagnostic procedures.
Pharmacokinetics
No direct human pharmacokinetic data published; estimates based on available limited animal and in vitro data. Methacholine exhibits rapid metabolism by cholinesterases and an extremely short plasma half-life. Typically administered via inhalation during bronchoprovocation challenge tests.
References
Short, PM, et al., & Lipworth, BJ (2015). Usefulness of impulse oscillometry for the assessment of airway hyperresponsiveness in mild-to-moderate adult asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 115(1) 17–20. DOI:10.1016/j.anai.2015.04.022 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26123421
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)