.Pharmacolibrary.Drugs.V_Various.V06D_OtherNutrients.V06DC02_Fructose.Fructose

Information

Fructose is a simple monosaccharide sugar commonly used as a sweetener in foods and is an ingredient in various intravenous infusion preparations, mainly as a component of parenteral nutrition solutions. Clinically, fructose solutions have been used in the past for energy supply, especially in patients requiring intravenous feeding. Its use is now limited, and it is not commonly used as a primary therapeutic agent due to concerns over its metabolic processing and adverse effects in some populations.

Pharmacokinetics

Pharmacokinetic parameters for intravenous administration in healthy adult volunteers; values are estimated based on published information for similar infusion solutions due to absence of direct clinical pharmacokinetic studies.

References

1. Yoon, Y, & Jagoda, A (2000). New antiepileptic drugs and preparations. Emergency medicine clinics of North America 18(4) 755–765. DOI:10.1016/s0733-8627(05)70157-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11130937

2. Ahmed, GF, et al., & Birnbaum, AK (2015). Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers. British journal of clinical pharmacology 79(5) 820–830. DOI:10.1111/bcp.12556 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25403343

3. Lim, CN, et al., & Marino, SE (2016). Pharmacokinetic-Pharmacodynamic Modeling of Intravenous and Oral Topiramate and Its Effect on the Symbol-Digit Modalities Test in Adult Healthy Volunteers. Journal of clinical pharmacology 56(6) 714–722. DOI:10.1002/jcph.646 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26395889

Revisions

• 06/2025 initial generated model