modelIohexol
Extends from Pharmacolibrary.Drugs.ATC.V.V08AB02.
Information
| name: | Iohexol | |
| ATC code: | V08AB02 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 350 | mg |
| volume of distribution: | 0.26 | L |
| clearance: | 107 | mL/min |
| other parameters in model implementation | ||
Iohexol is a non-ionic, water-soluble radiographic contrast agent commonly used in diagnostic imaging procedures such as computed tomography (CT) and angiography. It is typically administered intravenously and aids in the visualization of blood vessels and tissues. Iohexol is approved and widely used in clinical practice.
Pharmacokinetics
Pharmacokinetics in healthy adult volunteers after a single intravenous bolus injection; reported in a two-compartment model.
References
Baklouti, S, et al., & Cagnardi, P (2021). Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time. Frontiers in pharmacology 12 634404–None. DOI:10.3389/fphar.2021.634404 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33995036
Djerada, Z, et al., & Malinovsky, JM (2014). Population pharmacokinetics of nefopam in elderly, with or without renal impairment, and its link to treatment response. British journal of clinical pharmacology 77(6) 1027–1038. DOI:10.1111/bcp.12291 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24252055
Carrier, P, et al., & Loustaud-Ratti, V (2022). Iohexol plasma and urinary concentrations in cirrhotic patients: A pilot study. World journal of hepatology 14(8) 1621–1632. DOI:10.4254/wjh.v14.i8.1621 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36157874
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)