modelEthylEstersOfIodisedFatt
Extends from Pharmacolibrary.Drugs.ATC.V.V08AD01.
Information
| name: | EthylEstersOfIodisedFattyAcids | |
| ATC code: | V08AD01 | route: | intraarterial |
| compartments: | 1 | |
| dosage: | 10000 | mg |
| volume of distribution: | 3 | L |
| clearance: | 0.01 | L/h |
| other parameters in model implementation | ||
Ethyl esters of iodised fatty acids (e.g. iofetamine, ethiodized oil) are radiopaque contrast media primarily used in diagnostic radiology, particularly for lymphography and hysterosalpingography. They are not used systemically as pharmacological agents and are generally administered to enhance contrast in imaging rather than for therapeutic effects. The use of iodized fatty acid esters has diminished in favor of newer agents but may still be encountered for specific indications.
Pharmacokinetics
No published pharmacokinetic models describing classic parameter values for ethyl esters of iodised fatty acids in humans could be identified. The physicochemical properties of the drug (oil-based, retained for long periods in target tissues) and its typical administration route (intra-arterial or intralymphatic for radiological purposes) suggest very slow systemic clearance and limited systemic absorption.
References
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)