modelTechnetium99mtcButedroni
Extends from Pharmacolibrary.Drugs.ATC.V.V09BA04.
Information
| name: | Technetium99mtcButedronicAcid | |
| ATC code: | V09BA04 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 740 | mg |
| volume of distribution: | 0.3 | L |
| clearance: | 120 | mL/min |
| other parameters in model implementation | ||
Technetium (99mTc) butedronic acid, also known as 99mTc-3,3-diphosphono-1,2-propanedioic acid (99mTc-BPDA or 99mTc-BDP), is a radiopharmaceutical used primarily for bone scintigraphy to detect skeletal abnormalities, such as bone metastases, fractures, and other bone diseases. It binds strongly to hydroxyapatite in bone, facilitating imaging of bone metabolism. It is approved and in use for diagnostic nuclear medicine imaging procedures.
Pharmacokinetics
Estimated pharmacokinetic parameters based on available pharmacology information in the literature for adult patients undergoing bone scintigraphy. Exact compartmental pharmacokinetics for technetium (99mTc) butedronic acid are not published in the literature; parameters based on typical technetium-labeled bisphosphonates and bone imaging agents.
References
Castagnetti, M, et al., & Buxton-Thomas, M (2007). Hepatobiliary scintigraphy after Kasai procedure for biliary atresia: clinical correlation and prognostic value. Journal of pediatric surgery 42(6) 1107–1113. DOI:10.1016/j.jpedsurg.2007.01.063 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17560230
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)