.Pharmacolibrary.Drugs.V_Various.V09B_Skeleton.V09BA04_Technetium99mtcButedroni.Technetium99mtcButedroni

Information

Technetium (99mTc) butedronic acid, also known as 99mTc-3,3-diphosphono-1,2-propanedioic acid (99mTc-BPDA or 99mTc-BDP), is a radiopharmaceutical used primarily for bone scintigraphy to detect skeletal abnormalities, such as bone metastases, fractures, and other bone diseases. It binds strongly to hydroxyapatite in bone, facilitating imaging of bone metabolism. It is approved and in use for diagnostic nuclear medicine imaging procedures.

Pharmacokinetics

Estimated pharmacokinetic parameters based on available pharmacology information in the literature for adult patients undergoing bone scintigraphy. Exact compartmental pharmacokinetics for technetium (99mTc) butedronic acid are not published in the literature; parameters based on typical technetium-labeled bisphosphonates and bone imaging agents.

References

1. Castagnetti, M, et al., & Buxton-Thomas, M (2007). Hepatobiliary scintigraphy after Kasai procedure for biliary atresia: clinical correlation and prognostic value. Journal of pediatric surgery 42(6) 1107–1113. DOI:10.1016/j.jpedsurg.2007.01.063 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17560230

Revisions

• 06/2025 initial generated model