modelTechnetium99mtcVotumumab
Extends from Pharmacolibrary.Drugs.ATC.V.V09IA04.
Information
| name: | Technetium99mtcVotumumab | |
| ATC code: | V09IA04 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 0.5 | mg |
| volume of distribution: | 4 | L |
| clearance: | 0.2 | L/h |
| other parameters in model implementation | ||
Technetium (99mTc) votumumab is a radiopharmaceutical composed of the monoclonal antibody votumumab labeled with the radioisotope technetium-99m (99mTc). It was developed for tumor imaging, particularly targeting tumor necrosis and specific cancer antigens in diagnostic nuclear medicine. The drug was intended for use in cancer imaging, but is not widely approved or in mainstream clinical use today.
Pharmacokinetics
No published pharmacokinetic data available for technetium (99mTc) votumumab. The following PK parameters are estimated based on general properties of radiolabeled monoclonal antibodies administered intravenously for imaging purposes in adults.
References
Castronovo, FP (1981). Normal pharmacokinetics of 99mTc-diphosphonate after intravenous administration. Biopharmaceutics & drug disposition 2(3) 283–289. DOI:10.1002/bdd.2510020309 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7295885
Wong, M, et al., & Gurney, H (2006). Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 24(16) 2448–2455. DOI:10.1200/JCO.2005.02.1295 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16651648
Castagnetti, M, et al., & Buxton-Thomas, M (2007). Hepatobiliary scintigraphy after Kasai procedure for biliary atresia: clinical correlation and prognostic value. Journal of pediatric surgery 42(6) 1107–1113. DOI:10.1016/j.jpedsurg.2007.01.063 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17560230
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)