modelTechnetium99mtcArcitumom
Extends from Pharmacolibrary.Drugs.ATC.V.V09IA06.
Information
| name: | Technetium99mtcArcitumomab | |
| ATC code: | V09IA06 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 0.5 | mg |
| volume of distribution: | 3.5 | L |
| clearance: | 0.15 | L/h |
| other parameters in model implementation | ||
Technetium (99mTc) arcitumomab is a radiopharmaceutical agent composed of a murine monoclonal antibody (arcitumomab) labeled with the radionuclide technetium-99m. It binds to carcinoembryonic antigen (CEA) and is used in the diagnosis of colorectal cancer through gamma imaging to localize CEA-expressing tumors. It is not widely used today due to the development of more advanced imaging agents.
Pharmacokinetics
No peer-reviewed publications with detailed pharmacokinetic parameters (e.g., clearance, volume of distribution) for technetium (99mTc) arcitumomab in humans are available as of 2024-06. Dosing is reported to be typically intravenous, with imaging conducted 2–5 hours post-injection.
References
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)