.Pharmacolibrary.Examples.PK_2C_IVMidazolam .Pharmacolibrary.Examples.PK_2C_IVMidazolamPharmacokinetic of Midazolam administered - 2-compartment model example with parameter values, dosage 9.6 mg administered intravenously with bioavailability 1.
Midazolam—a fast-acting benzodiazepine used for sedation, anxiolysis, and anesthesia induction—exemplifies a drug whose intravenous pharmacokinetics are well described by a two-compartment model. The plasma concentration requiredfor anesthesia induction must remain above a defined minimal effective threshold Cmin.
Simulation and experimental data from the paper of Heizmann et al. [1] from the subject O.A, as made open at https://pk-db.com/api/v1/subsets/5193/?format=json
[1] Heizmann, P., Eckert, M. and Ziegler, W. (1983), Pharmacokinetics and bioavailability of midazolam in man.. British Journal of Clinical Pharmacology, 16: 43S-49S. https://doi.org/10.1111/j.1365-2125.1983.tb02270.x