.Pharmacolibrary.Pharmacodynamic.FirstOrderInhibitionEffect

indirect first order inhibition effect model

Information

FirstOrderInhibitionEffect

indirect first order inhibition effect model. Effect E is calculated using an differential equation

                        c  
E' = kIn - kOut*(1 - ---------)*E
                      c + c50

where c is the free concentration (either tissue or blood/plasma, depending on the switch) at the BloodTissueConcentrationPort connector.

Parameters

c50 - concentration producing 50% maximum inhibition
kIn - zero-order response production constant
kOut - first-order response loss rate constant
Boolean cBSwitch - false: use tissue free conc, true: use blood free conc

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