.Pharmacolibrary.Pharmacodynamic.FirstOrderStimulationEffect

indirect first order stimulation effect model

Information

FirstOrderStimulationEffect

indirect first order stimulation effect model. Effect E is calculated using an differential equation

                      Emax * c  
E' = kIn - kOut*(1 + ----------)*E
                      c + c50

where c is the free concentration (either tissue or blood/plasma, depending on the switch) at the BloodTissueConcentrationPort connector.

Parameters

Emax - maximal effect
c50 - concentration producing 50% of maximum stimulation
kIn - zero-order response production constant
kOut - first-order response loss rate constant
Boolean cBSwitch - false: use tissue free conc, true: use blood free conc
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