ZeroOrderInhibitionEffect
indirect zero order inhibition effect model. Effect E is calculated using an differential equation
c
E' = kIn*(1 - ---------) - kOut*E
c + c50
where c is the free concentration (either tissue or blood/plasma, depending on the switch) at the BloodTissueConcentrationPort connector.
Parameters
c50 - concentration producing 50% maximum inhibition
kIn - zero-order response production constant
kOut - first-order response loss rate constant
Boolean tissueBloodSw - false: use tissue free conc, true: use blood free conc
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.Pharmacolibrary.Pharmacodynamic.ZeroOrderInhibitionEffect