.Pharmacolibrary.Pharmacodynamic.ZeroOrderInhibitionEffect

Information

ZeroOrderInhibitionEffect

indirect zero order inhibition effect model. Effect E is calculated using the differential equation

                 c  
E' = kIn*(1 - ---------) - kOut*E
               c + c50

where c is the free concentration (either tissue or blood/plasma at the concentrationPort connector.

Parameters

c50 - concentration producing 50% maximum inhibition
kIn - zero-order response production constant
kOut - first-order response loss rate constant



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