indirect zero order stimulation effect modelZeroOrderStimulationEffect
indirect zero order stimulation effect model. Effect E is calculated using an differential equation
Emax * c
E' = kIn*(1 + ----------) - kOut*E
c + c50
where c is the free concentration (either tissue or blood/plasma, depending on the switch) at the BloodTissueConcentrationPort connector.
Parameters
Emax - maximal effect
c50 - concentration producing 50% of maximum stimulation
kIn - zero-order response production constant
kOut - first-order response loss rate constant
Boolean cBSwitch - false: use tissue free conc, true: use blood free conc
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.Pharmacolibrary.Pharmacodynamic.ZeroOrderStimulationEffect