Ca Oscillations
This example is a Modelica version of the model presented in A Minimal Generic Model of Bacteria-Induced Intracellular Ca2+
Oscillations in Epithelial Cells by Camilla Oxhamre, Agneta Richter-Dahlfors, Vladimir P. Zhdanov, and Bengt Kasemoy. (Biophysical Journal Volume 88 April 2005 2976-2981)
Abstract
The toxin &alpha-hemolysin expressed by uropathogenic Escherichia coli bacteria was recently shown as the first
pathophysiologically relevant protein to induce oscillations of the intracellular Ca2+ concentration in target cells. Here, we
propose a generic three-variable kinetic model describing the Ca2+ oscillations induced in single rat renal epithelial cells by this
toxin. Specifically, we take into account the interplay between 1), the cytosolic Ca2+ concentration; 2), IP3-sensitive Ca2+
channels located in the membrane separating the cytosol and endoplasmic reticulum; and 3), toxin-related activation of
production of IP3 by phospholipase C. With these ingredients, the predicted response of cells exposed to the toxin is in good
agreement with the results of experiments.
Simulations
The simulation results are shown in the
Figure 1. This plot corresponds to Fig 1C of the paper (Oxhamre 2005).
Contents
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