modelcytosol

Information

<h1>Cytosol</h1>
<a name="fig1"></a>
<img src="resources/BioChem/Resources/Images/figure1.jpg" width="640px" height="446px" alt="Fig1: Biochemical scheme">
<p><em><strong>Fig. 1.</strong> Scheme of glycolysis and coupled processes simulated in the model: consumption and synthesis of ATP and transformation of reducing equivalents of NADH. The relevant equations, which account for stoicheiometry of the ATP production, are given in Supplementary materials. One molecule of ATP is consumed per molecule of fructose 6-phosphate in the phosphofructokinase reaction; two molecules of ATP per molecule of triose phospate (four molecules per hexose molecule) are then produced on the way to pyruvate; 2.5 molecules of ATP are produced when one molecule of NADH is oxidized. Cytosolic NADH is produced in the reaction of glyceraldehyde-3-phosphate dehydrogenase and consumed when pyruvate is transformed to lactate. In mitochondria one molecule of NADH is produced in the pyruvate dehydrogenase reaction and then three NADH molecules and one FADH2 molecule in the tricarboxylate cycle. Abbreviations: AK, adenylate kinase (EC 2.7.4.3); CK, creatine kinase (EC 2.7.3.2); CP, phosphocreatine; Cr, creatine; F6P, fructose 6-phosphate; FBP, fructose 1,6-bisphosphate; G6P, glucose 6-phosphate; GAPDH, glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12);
GPh, glycogen phosphorylase (EC 2.4.1.1); Lac, lactate; LDH, lactate dehydrogenase (EC 1.1.1.27); PFK, phosphofructokinase (EC 2.7.1.11); GPI, glucose phosphate isomerase (EC 5.3.1.9.); Pyr, pyruvate. Subscripts: m, mitochondrial; c, cytosolic.</em></p>

Parameters

Connectors

Components

Contents

Name	Description
DHAP_
G3P_
NADH_
FDP_
PYR_
ADP_
IMP_
ATP_
AMP_
LAC_
NAD_
CP_
Cr_
GLY_
PN_
G6P_
F6P_
jda_
vgpdh_
vpfk_
vald_
vldh_
vpdh_
jak_
vgph_
jatpase_
jck_