modelHemoglobin_titration
Hemoglobin titration experiment
Extends from Modelica.Icons.Example (Icon for runnable examples), SteadyStates.Interfaces.SteadyStateSystem (Global abstract class, for additional global state equations).
Information
[1] Siggaard-Andersen O, Garby L. The Bohr effect and the Haldane effect. Scandinavian Journal of Clinical & Laboratory Investigation 1973;31:1-8.
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Fraction | L | 7.0529*10^6 | =[T0]/[R0] .. dissociation constant of relaxed <-> tensed change of deoxyhemoglobin tetramer |
| Fraction | Ln | 26884.8 | quaternaly form ratio for specific stripped species of hemoglobin tetramer |
| Fraction | c | 0.00431555 | =KR/KT .. ration between oxygen affinities of relaxed vs. tensed subunit |
| Concentration | KR | 0.000671946 | oxygen dissociation on relaxed(R) hemoglobin subunit |
| Concentration | KT | KR/c | oxygen dissociation on tensed(T) hemoglobin subunit |
| AmountOfSubstance | totalAmountOfHemoglobin | 0.001 | |
| Simulation › Simulation type | |||
| Types.SimulationType | Simulation (from SteadyStateSystem) | Dynamic with Initialization or Steady State | |
| Simulation › Equilibrium | |||
| Integer | NumberOfDependentStates (from SteadyStateSystem) | 1 | Number of additional steady state equation of the system |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.RealIO.FractionOutput | protonation | allosteric-dependent protonation |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Real[NumberOfDependentStates] | normalizedState (from SteadyStateSystem) | Normalized independent masses of the system/Normalized independent energies of the system/... This variables must always equals to ones. | |
| Components.Substance | oxygen_unbound | ||
| Modelica.Blocks.Sources.ContinuousClock | clock | ||
| Sources.UnlimitedGasStorage | oxygen_in_air | ||
| Components.GasSolubility | partialPressure1 | ||
| Sources.UnlimitedSolutionStorage | pH | ||
| Sources.UnlimitedGasStorage | CO2_gas | ||
| Components.GasSolubility | gasSolubility | ||
| Components.Substance | CO2_liquid | ||
| Hemoglobin2 | deoxyhemoglobin | ||
| Blocks.Math.Power | pow | ||
| Modelica.Blocks.Math.Gain | gain | ||
| Modelica.Blocks.Math.Gain | toMolPerM3 | from mol/liter to mmol/liter (=mol/m3) |
Revisions
2014
Marek Matejak, Charles University, Prague, Czech Republic