.Pharmacolibrary.Drugs.D_Dermatologicals.D06A_AntibioticsForTopicalUse.D06AX07_Gentamicin.Gentamicin

Information

Gentamicin is an aminoglycoside antibiotic used primarily to treat various types of bacterial infections, especially those caused by Gram-negative organisms. It is commonly used for severe systemic infections such as sepsis, respiratory tract infections, urinary tract infections, and intra-abdominal infections. Gentamicin is still approved and in clinical use today, typically administered parenterally due to poor gastrointestinal absorption.

Pharmacokinetics

Pharmacokinetic parameters reported for adult healthy volunteers; intravenous administration.

References

1. Medellín-Garibay, SE, et al., & Barcia, E (2015). Population pharmacokinetics of gentamicin and dosing optimization for infants. Antimicrobial agents and chemotherapy 59(1) 482–489. DOI:10.1128/AAC.03464-14 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25385111

2. Boisson, M, et al., & Grégoire, N (2018). Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. The Journal of antimicrobial chemotherapy 73(10) 2830–2837. DOI:10.1093/jac/dky239 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947799

3. Lares-Asseff, I, et al., & Lugo Goytia, G (2016). Population Pharmacokinetics of Gentamicin in Mexican Children With Severe Malnutrition. The Pediatric infectious disease journal 35(8) 872–878. DOI:10.1097/INF.0000000000001204 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27420805

Revisions

• 06/2025 initial generated model