.Pharmacolibrary.Drugs.D_Dermatologicals.D10A_AntiAcnePreparationsForTopicalUse.D10AX05_Dapsone.Dapsone

Information

Dapsone is an antibacterial sulfone drug primarily used for the treatment of leprosy (Hansen's disease), dermatitis herpetiformis, and as a prophylactic treatment for Pneumocystis jirovecii pneumonia in immunocompromised patients. Dapsone is still approved and in use today, especially in combination therapy for leprosy and for certain skin conditions.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after a single oral 100 mg dose.

References

1. Mirochnick, M, et al., & Spector, SA (2001). Population pharmacokinetics of dapsone in children with human immunodeficiency virus infection. Clinical pharmacology and therapeutics 70(1) 24–32. DOI:10.1067/mcp.2001.115891 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11452241

2. Mirochnick, M, et al., & McNamara, J (1999). Pharmacokinetics of dapsone administered daily and weekly in human immunodeficiency virus-infected children. Antimicrobial agents and chemotherapy 43(11) 2586–2591. DOI:10.1128/AAC.43.11.2586 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10543733

3. Gatti, G, et al., & Bassetti, D (1995). Pharmacokinetics of dapsone in human immunodeficiency virus-infected children. Antimicrobial agents and chemotherapy 39(5) 1101–1106. DOI:10.1128/AAC.39.5.1101 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7625796

Revisions

• 06/2025 initial generated model