.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G04B_Urologicals.G04BX16_Tiopronin.Tiopronin .Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G04B_Urologicals.G04BX16_Tiopronin.Tiopronin| name: | Tiopronin | |
| ATC code: | G04BX16 | route: | oral |
| compartments: | 1 | |
| dosage: | 300 | mg |
| volume of distribution: | 0.36 | L |
| clearance: | 28 | L/h |
| other parameters in model implementation | ||
Tiopronin is a thiol-containing compound used primarily for the prevention of cystine stone formation in patients with severe homozygous cystinuria. It acts by forming a mixed disulfide with cystine, making it more soluble and thus preventing stone formation. Tiopronin is an FDA-approved medication and remains available for clinical use.
Pharmacokinetic parameters estimated for a typical adult population (18-65 years, both sexes, without significant renal or hepatic impairment). Specific PK studies in humans are limited.