modelTreosulfan_1
Extends from Pharmacolibrary.Drugs.ATC.L.L01AB02_1.
Information
| name: | Treosulfan_1 | |
| ATC code: | L01AB02_1 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 10 | mg |
| volume of distribution: | 9.1 | L |
| clearance: | 2.75 | L/h |
| other parameters in model implementation | ||
Treosulfan is an alkylating agent used in conditioning regimens prior to hematopoietic stem cell transplantation (HSCT), mainly for treatment of hematological malignancies and some non-malignant diseases. It is currently approved and in clinical use in several countries for both adults and children as a part of preparative regimens for transplantation.
Pharmacokinetics
Pharmacokinetic parameters reported in pediatric patients undergoing hematopoietic stem cell transplantation receiving intravenous treosulfan. Mean values from a pediatric population PK model.
References
Rosser, SPA, et al., & Nath, CE (2023). Evaluation of treosulfan cumulative exposure in paediatric patients through population pharmacokinetics and dosing simulations. British journal of clinical pharmacology 89(4) 1413–1424. DOI:10.1111/bcp.15599 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36369677
Danielak, D, et al., & Główka, F (2018). Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation. European journal of clinical pharmacology 74(1) 79–89. DOI:10.1007/s00228-017-2344-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/28975382
Li, X, et al., & Sykora, KW (2023). Population pharmacokinetic modeling of treosulfan and rationale for dose recommendation in children treated for conditioning prior to allogeneic hematopoietic stem cell transplantation. Drug metabolism and pharmacokinetics 52 100515–None. DOI:10.1016/j.dmpk.2023.100515 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37481830
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)