modelThiotepa_1
Extends from Pharmacolibrary.Drugs.ATC.L.L01AC01_1.
Information
| name: | Thiotepa_1 | |
| ATC code: | L01AC01_1 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 200 | mg |
| volume of distribution: | 1.56 | L |
| clearance: | 31 | mL/min/kg |
| other parameters in model implementation | ||
Thiotepa is an alkylating agent of the ethyleneimine type, used primarily as an antineoplastic chemotherapy drug. It has been indicated for use in the treatment of various cancers including breast cancer, ovarian cancer, and bladder cancer. Thiotepa is approved for use as a conditioning treatment prior to hematopoietic stem cell transplantation and for high-dose chemotherapy settings.
Pharmacokinetics
Pharmacokinetic parameters reported for pediatric patients undergoing stem cell transplantation using intravenous thiotepa.
References
de Jonge, ME, et al., & Beijnen, JH (2005). Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin. Therapeutic drug monitoring 27(6) 756–765. DOI:10.1097/01.ftd.0000177224.19294.92 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16306851
Huitema, AD, et al., & Beijnen, JH (2000). Validation of techniques for the prediction of carboplatin exposure: application of Bayesian methods. Clinical pharmacology and therapeutics 67(6) 621–630. DOI:10.1067/mcp.2000.106827 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10872644
van Warmerdam, LJ, et al., & Beijnen, JH (1994). Validation of a limited sampling model for carboplatin in a high-dose chemotherapy combination. Cancer chemotherapy and pharmacology 35(2) 179–181. DOI:10.1007/BF00686644 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7987998
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)