modelMebendazole
Extends from Pharmacolibrary.Drugs.ATC.P.P02CA01.
Information
| name: | Mebendazole | |
| ATC code: | P02CA01 | route: | oral |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 1 | L |
| clearance: | 200 | ml/min |
| other parameters in model implementation | ||
Mebendazole is a broad-spectrum anthelmintic drug used for the treatment of various helminthic infections such as ascariasis, hookworm, whipworm, and pinworm. It is listed as an essential medicine by the WHO and remains an approved and widely used medication for parasitic worm infections in both adults and children.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers following a single oral dose.
References
Ceballos, L, et al., & Lanusse, CE (2018). Assessment of serum pharmacokinetics and urinary excretion of albendazole and its metabolites in human volunteers. PLoS neglected tropical diseases 12(1) e0005945–None. DOI:10.1371/journal.pntd.0005945 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29346367
Villaverde, C, et al., & Prieto, JG (1992). Albendazole and mebendazole uptake by isolated enterocytes. Developmental pharmacology and therapeutics 19(1) 27–31. DOI:10.1159/000457459 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1307343
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)