.Pharmacolibrary.Drugs.R_RespiratorySystem.R01A_DecongestantsAndOtherNasalPreparationsForTopical.R01AC03_Azelastine.Azelastine

Information

name:Azelastine
ATC code:R01AC03
route:intranasal
n-compartments1

Azelastine is a second-generation antihistamine used primarily as a nasal spray or eye drop for the symptomatic treatment of allergic rhinitis and allergic conjunctivitis. It works by selectively antagonizing histamine H1 receptors, thereby reducing allergy symptoms. Azelastine is approved and in clinical use today.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after intranasal administration.

References

  1. Wolthers, OD (2013). New patents of fixed combinations of nasal antihistamines and corticosteroids in allergic rhinitis. Recent patents on inflammation & allergy drug discovery 7(3) 223–228. DOI:10.2174/1872213x113079990019 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23862774

  2. Simons, FE, & Simons, KJ (1999). Clinical pharmacology of new histamine H1 receptor antagonists. Clinical pharmacokinetics 36(5) 329–352. DOI:10.2165/00003088-199936050-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10384858

Revisions

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