.Pharmacolibrary.Drugs.R_RespiratorySystem.R01B_NasalDecongestantsForSystemicUse.R01BA03_Phenylephrine.Phenylephrine .Pharmacolibrary.Drugs.R_RespiratorySystem.R01B_NasalDecongestantsForSystemicUse.R01BA03_Phenylephrine.Phenylephrine| name: | Phenylephrine |
| ATC code: | R01BA03 | route: | oral |
| n-compartments | 1 |
Phenylephrine is a selective alpha-1 adrenergic receptor agonist primarily used as a decongestant in the treatment of nasal congestion and hypotension. It is commonly used in over-the-counter cold and allergy medications and as a vasopressor to increase blood pressure in clinical settings. Phenylephrine is approved for use in many countries and is widely available.
Pharmacokinetic parameters reported for healthy adult volunteers after oral administration.
Atkinson, HC, et al., & Anderson, BJ (2015). Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review. European journal of clinical pharmacology 71(8) 931–938. DOI:10.1007/s00228-015-1876-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26022219
Atkinson, HC, et al., & Anderson, BJ (2015). Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers. European journal of clinical pharmacology 71(2) 151–158. DOI:10.1007/s00228-014-1788-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25475358
Vincent, J, et al., & Reid, JL (1986). Racial differences in drug responses--a comparative study of trimazosin and alpha 1-adrenoceptor responses in normotensive Caucasians and West Africans. British journal of clinical pharmacology 21(4) 401–408. DOI:10.1111/j.1365-2125.1986.tb05214.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/3011048