.Pharmacolibrary.Drugs.R_RespiratorySystem.R03B_OtherDrugsForObstructiveAirwayDiseasesInhalants.R03BA08_Ciclesonide.Ciclesonide .Pharmacolibrary.Drugs.R_RespiratorySystem.R03B_OtherDrugsForObstructiveAirwayDiseasesInhalants.R03BA08_Ciclesonide.Ciclesonide| name: | Ciclesonide |
| ATC code: | R03BA08 | route: | inhalation |
| n-compartments | 2 |
Ciclesonide is an inhaled corticosteroid used in the prophylactic treatment of asthma and allergic rhinitis. It is a prodrug that is activated in the lungs to its active metabolite, des-ciclesonide. Ciclesonide is approved and commonly used today for asthma maintenance therapy.
Pharmacokinetic parameters reported for healthy adult subjects after inhalation administration of ciclesonide.
Rohatagi, S, et al., & Barrett, JS (2003). Population pharmacokinetics and pharmacodynamics of ciclesonide. Journal of clinical pharmacology 43(4) 365–378. DOI:10.1177/0091270002250998 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12723457
Xu, J, et al., & Derendorf, H (2010). Population pharmacokinetics and pharmacodynamics of inhaled ciclesonide and fluticasone propionate in patients with persistent asthma. Journal of clinical pharmacology 50(10) 1118–1127. DOI:10.1177/0091270009354994 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20150524
Teramoto, T, et al., & Nishima, S (2012). Repeated-dose pharmacokinetics of inhaled ciclesonide (CIC-HFA) in Japanese children with bronchial asthma: a phase I study. Allergology international : official journal of the Japanese Society of Allergology 61(4) 619–624. DOI:10.2332/allergolint.11-OA-0378 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23000724