.Pharmacolibrary.Drugs.R_RespiratorySystem.R05D_CoughSuppressantsExclCombinationsWithExpectorant.R05DA04_Codeine.Codeine

Information

Codeine is an opioid analgesic used for the relief of mild to moderate pain and as an antitussive to suppress cough. It is frequently combined with other analgesics such as paracetamol or ibuprofen. Codeine is still approved and used today in many countries, although its use is controlled due to potential for abuse and variable metabolism.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after oral administration of codeine phosphate.

References

1. Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834

2. Gretler, SR, et al., & Knych, HK (2020). Metabolism, pharmacokinetics and selected pharmacodynamic effects of codeine following a single oral administration to horses. Veterinary anaesthesia and analgesia 47(5) 694–704. DOI:10.1016/j.vaa.2020.04.004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32654915

3. Knych, HK, et al., & McKemie, DS (2022). Pharmacokinetics, adverse effects and effects on thermal nociception following administration of three doses of codeine to horses. BMC veterinary research 18(1) 196–None. DOI:10.1186/s12917-022-03299-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35614473

Revisions

• 06/2025 initial generated model