.Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AX19_Azelastine.Azelastine_1 .Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AX19_Azelastine.Azelastine_1| name: | Azelastine_1 | |
| ATC code: | R06AX19_1 | route: | oral |
| compartments: | 1 | |
| dosage: | 4 | mg |
| volume of distribution: | 14.5 | L |
| clearance: | 0.5 | L/h/kg |
| other parameters in model implementation | ||
Azelastine is a selective histamine H1 receptor antagonist with additional anti-inflammatory and mast cell stabilizing properties. It is primarily used for the symptomatic relief of allergic rhinitis and conjunctivitis. It is available as a nasal spray and ophthalmic solution, and is approved for use in many countries, including for prescription and over-the-counter use.
PK parameters reported for healthy adults after single oral administration.
Simons, FE, & Simons, KJ (1999). Clinical pharmacology of new histamine H1 receptor antagonists. Clinical pharmacokinetics 36(5) 329–352. DOI:10.2165/00003088-199936050-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10384858
Adusumalli, VE, et al., & Sofia, RD (1993). Pharmacokinetics of the new antiasthma and antiallergy drug, azelastine, in pediatric and adult beagle dogs. Biopharmaceutics & drug disposition 14(3) 233–244. DOI:10.1002/bdd.2510140306 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8098227