.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AA28_Vancomycin.Vancomycin

Information

Vancomycin is a glycopeptide antibiotic widely used for the treatment of serious Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus (MRSA). It is primarily administered intravenously due to poor oral absorption and is approved for use in hospitals and clinical settings worldwide.

Pharmacokinetics

Pharmacokinetic parameters reported for adult patients with normal renal function after intravenous administration.

References

1. Goyal, RK, et al., & Al Mohajer, M (2022). Population Pharmacokinetics of Vancomycin in Pregnant Women. Frontiers in pharmacology 13 873439–None. DOI:10.3389/fphar.2022.873439 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35734401

2. Chen, Z, et al., & Liebchen, U (2023). Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Vancomycin in Patients with External Ventricular Drain. Antimicrobial agents and chemotherapy 67(6) e0024123–None. DOI:10.1128/aac.00241-23 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37162349

3. Yu, Z, et al., & Zhao, Y (2023). Population pharmacokinetics and individualized dosing of vancomycin for critically ill patients receiving continuous renal replacement therapy: the role of residual diuresis. Frontiers in pharmacology 14 1298397–None. DOI:10.3389/fphar.2023.1298397 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38223197

Revisions

• 06/2025 initial generated model