modelFlumazenil
Extends from Pharmacolibrary.Drugs.ATC.V.V03AB25.
Information
| name: | Flumazenil | |
| ATC code: | V03AB25 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 0.5 | mg |
| volume of distribution: | 0.7 | L |
| clearance: | 0.9 | L/min |
| other parameters in model implementation | ||
Flumazenil is an imidazobenzodiazepine derivative used as a selective benzodiazepine receptor antagonist. It is primarily used for the reversal of benzodiazepine sedation during anesthesia and for the management of benzodiazepine overdose. Flumazenil is approved for clinical use and acts rapidly to counteract the central effects of benzodiazepines.
Pharmacokinetics
Pharmacokinetic data reported for healthy adult volunteers following intravenous administration of flumazenil.
References
Rousseau-Blass, F, et al., & Pang, DS (2021). A Pharmacokinetic-Pharmacodynamic Study of Intravenous Midazolam and Flumazenil in Adult New Zealand White-Californian Rabbits (. Journal of the American Association for Laboratory Animal Science : JAALAS 60(3) 319–328. DOI:10.30802/AALAS-JAALAS-20-000084 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33673881
Karavokiros, KA, & Tsipis, GB (1990). Flumazenil: a benzodiazepine antagonist. DICP : the annals of pharmacotherapy 24(10) 976–981. DOI:10.1177/106002809002401013 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2244412
Waugaman, WR, & Foster, SD (1991). New advances in anesthesia. The Nursing clinics of North America 26(2) 451–461. PUBMED:https://pubmed.ncbi.nlm.nih.gov/2047291
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)