.Pharmacolibrary.Drugs.V_Various.V03A_AllOtherTherapeuticProducts.V03AB38_AndexanetAlfa.AndexanetAlfa .Pharmacolibrary.Drugs.V_Various.V03A_AllOtherTherapeuticProducts.V03AB38_AndexanetAlfa.AndexanetAlfa| name: | AndexanetAlfa | |
| ATC code: | V03AB38 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 800 | mg |
| volume of distribution: | 5.3 | L |
| clearance: | 4.1 | L/h |
| other parameters in model implementation | ||
Andexanet alfa is a recombinant modified human factor Xa decoy protein used to reverse the anticoagulant effects of direct and indirect factor Xa inhibitors, such as apixaban and rivaroxaban, in cases of life-threatening or uncontrolled bleeding. It is approved for use in adults by the FDA.
Pharmacokinetic model described for healthy adult volunteers following intravenous bolus followed by continuous infusion.