modelDeferiprone
Extends from Pharmacolibrary.Drugs.ATC.V.V03AC02.
Information
| name: | Deferiprone | |
| ATC code: | V03AC02 | route: | oral |
| compartments: | 1 | |
| dosage: | 25 | mg |
| volume of distribution: | 1.6 | L |
| clearance: | 0.16 | L/h/kg |
| other parameters in model implementation | ||
Deferiprone is an oral iron chelator primarily used for the treatment of iron overload in patients with thalassemia major and other chronic anemias, especially when standard chelation therapy is inadequate or contraindicated. It is approved and in use for this indication.
Pharmacokinetics
Pharmacokinetic parameters reported from studies in adult patients (both sexes) with thalassemia major receiving oral deferiprone under steady-state conditions.
References
Bellanti, F, et al., & Della Pasqua, O (2014). Population pharmacokinetics of deferiprone in healthy subjects. British journal of clinical pharmacology 78(6) 1397–1406. DOI:10.1111/bcp.12473 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25052529
Soulières, D, et al., & Tricta, F (2022). The pharmacokinetic and safety profile of single-dose deferiprone in subjects with sickle cell disease. Annals of hematology 101(3) 533–539. DOI:10.1007/s00277-021-04728-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34981144
Bellanti, F, et al., & Della Pasqua, O (2016). Sampling Optimization in Pharmacokinetic Bridging Studies: Example of the Use of Deferiprone in Children With β-Thalassemia. Journal of clinical pharmacology 56(9) 1094–1103. DOI:10.1002/jcph.708 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26785826
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)