.Pharmacolibrary.Drugs.V_Various.V03A_AllOtherTherapeuticProducts.V03AX04_Difelikefalin.Difelikefalin .Pharmacolibrary.Drugs.V_Various.V03A_AllOtherTherapeuticProducts.V03AX04_Difelikefalin.Difelikefalin| name: | Difelikefalin | |
| ATC code: | V03AX04 | |
| route: | intravenous | |
| compartments: | 2 | |
| dosage: | 0.5 | mg |
| volume of distribution: | 11.5 | L |
| clearance: | 3.4 | L/h |
| other parameters in model implementation | ||
Difelikefalin is a selective kappa opioid receptor agonist, used for the treatment of moderate-to-severe pruritus associated with chronic kidney disease in adults undergoing hemodialysis. It is approved for medical use and acts peripherally with minimal crossing of the blood-brain barrier, reducing the risk of central opioid side effects.
Pharmacokinetic parameters reported for adult patients undergoing hemodialysis, following intravenous administration.