The pharmacodynamic components outputs the effect based on concentration in target tissue. An example of PKPD model of Midazolam where pharmacokinetic part is modeled using 2-compartment model and central compartment is connected to sigmoid effect component.
Cleton, A, R A Voskuyl, and M Danhof (1998-10). “Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy: Epilepsy induced reduction in midazolam efficacy”. en. In: Br. J. Pharmacol. 125.4,pp. 615–620. ISSN: 0007-1188,1476-5381. DOI: 10.1038/sj.bjp.0702088. URL: http://dx.doi.org/10.1038/sj.bjp.0702088
.Pharmacolibrary.Examples.PKPD_Midazolam