modelBloodGases

Hydrogen Ion, Carbon Dioxide, and Oxygen in the Blood
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Information

Hydrogen Ion, Carbon Dioxide, and Oxygen in the Blood (siggaard-andersen.dk)

Medsoft_2013_Matejak.pdf (creativeconnections.cz)

Parameters

TypeNameDefaultDescription
Physiolibrary.Types.TemperatureT0273.15 + 37normal temperature
Physiolibrary.Types.pHpH07.4normal pH
Physiolibrary.Types.pHpH_ery07.19normal pH in erythrocyte
Physiolibrary.Types.PressurepCO20(40/760)*101325normal CO2 partial pressure
RealpKa12.1HPO4^2- dissociation
RealpKa26.8H2PO4^- dissociation
RealpKa312.7H3PO4 dissociation
RealbetaOxyHb3.1Buffer value for oxygenated Hb without CO2
RealpIo7.13Isoelectric pH for oxygenated Hb without CO2
RealpKzD7.73Coefficient pKa for NH3+ end of deoxygenated hemoglobin chain
RealpKzO7.25Coefficient pKa for NH3+ end of oxygenated hemoglobin chain
RealpKcD7.5410^(pH-pKcR) is the dissociation constatnt for HbNH2 + CO2 <-> HbNHCOO- + H+
RealpKcO8.3510^(pH-pKcO) is the dissociation constatnt for O2HbNH2 + CO2 <-> O2HbNHCOO- + H+
RealpKhD7.5210^(pH-pKhD) is the dissociation constatnt for HbAH <-> HbA- + H+
RealpKhO6.8910^(pH-pKhO) is the dissociation constatnt for O2HbAH <-> O2HbA- + H+

Components

TypeNameDefaultDescription
Physiolibrary.Media.Blood.ThermodynamicStatestateblood
Modelica.Units.SI.TemperatureT310.15Temperature
Modelica.Units.SI.PressurepO2Oxygen partial pressure
Modelica.Units.SI.PressurepCO2Carbon dioxide partial pressure
Modelica.Units.SI.PressurepCOCarbon monoxide partial pressure
Physiolibrary.Types.pHpHBlood plasma acidity
Physiolibrary.Types.VolumeFractionHcthematocrit(state)haematocrit
Types.Concentration_tO2tO2(state)oxygen content per volume of blood
Types.Concentration_tCO2tCO2(state)carbon dioxide content per volume of blood
Types.Concentration_tCOtCO(state)carbon monoxide content per volume of blood
Types.Concentration_tHbtHb(state)hemoglobin content per volume of blood
Types.MoleFraction_FMetHbFMetHb(state)fraction of methemoglobin
Types.MoleFraction_FHbFFHbF(state)fraction of foetalhemoglobin
Types.Concentration_ctHb_eryctHb_ery(state)hemoglobin concentration in red cells
Types.Concentration_tAlbtAlb(state)albumin concentration in blood plasma
Types.MassConcentration_tGlbtGlb(state)globulin concentration in blood plasma
Types.Concentration_tPO4tPO4(state)inorganic phosphates concentration in blood plasma
Types.Concentration_cDPGcDPG(state)DPG concentration in blood plasma
Types.Concentration_SIDSID(state)strong ion difference of blood
Physiolibrary.Types.ConcentrationNSIDP
Physiolibrary.Types.ConcentrationNSIDE
Physiolibrary.Types.ConcentrationNSID
Physiolibrary.Types.ConcentrationBEox
Physiolibrary.Types.ConcentrationcdCO2
Physiolibrary.Types.pHpH_ery
Physiolibrary.Types.GasSolubilityPaaCO2N0.00023solubility of CO2 in blood plasma at 37 degC
Physiolibrary.Types.GasSolubilityPaaCO20.00023*(10^(-0.0092*(T - 310.15)))solubility of CO2 in blood plasma
Physiolibrary.Types.GasSolubilityPaaCO2_ery0.000195solubility 0.23 (mmol/l)/kPa at 25degC
Physiolibrary.Types.GasSolubilityPaaO2exp(log(0.0105) + (-0.0115*(T - T0)) + 0.5*0.00042*((T - T0)^2))/1000oxygen solubility in blood
Physiolibrary.Types.GasSolubilityPaaCO(0.00099/0.0013)*aO2carbon monoxide solubility in blood
RealpK6.1 + (-0.0026)*(T - 310.15)Henderson-Hasselbalch
RealpK_ery6.125 - log10(1 + 10^(pH_ery - 7.84 - 0.06*sO2))
Physiolibrary.Types.ConcentrationcdCO2N
Physiolibrary.Types.FractionsCO2N
Physiolibrary.Types.FractionfzcON
Physiolibrary.Types.Concentrationbeta
Physiolibrary.Types.ConcentrationcHCO3
Physiolibrary.Types.ConcentrationcHCO3_E
Physiolibrary.Types.FractionsO2CO
Physiolibrary.Types.FractionsCO
Physiolibrary.Types.FractionsO2
Physiolibrary.Types.FractionFCOHb
Physiolibrary.Types.ConcentrationceHbeffective hemoglobin
Physiolibrary.Types.ConcentrationtCO2_P
Physiolibrary.Types.ConcentrationtCO2_ery