Ref: Mateják Marek, Kulhánek Tomáa, Matouaek Stanislav. Adair-Based Hemoglobin Equilibrium with Oxygen, Carbon Dioxide and Hydrogen Ion Activity. Scandinavian Journal of Clinical & Laboratory Investigation 2014
Before silumation in "Dymola 2014 FD01" please set environment variable "Advanced.Define.NonLinearIterations = 3" and chose "Euler" method!
Parameters are chosen to fit following measurements:
[1] Bauer C, Schröder E. Carbamino compounds of haemoglobin in human adult and foetal blood. The Journal of physiology 1972;227:457-71.
[2] Siggaard-Andersen O. Oxygen-Linked Hydrogen Ion Binding of Human Hemoglobin. Effects of Carbon Dioxide and 2, 3-Diphosphoglycerate I. Studies on Erythrolysate. Scandinavian Journal of Clinical & Laboratory Investigation 1971;27:351-60.
[3] Severinghaus JW. Simple, accurate equations for human blood O2 dissociation computations. Journal of Applied Physiology 1979;46:599-602.
2014
Marek Matejak, Charles University, Prague, Czech Republic