modelHemoglobin_MKM_Adair
Information
Ref: Mateják Marek, Kulhánek Tomáa, Matouaek Stanislav. Adair-Based Hemoglobin Equilibrium with Oxygen, Carbon Dioxide and Hydrogen Ion Activity. Scandinavian Journal of Clinical & Laboratory Investigation 2014
Before silumation in "Dymola 2014 FD01" please set environment variable "Advanced.Define.NonLinearIterations = 3" and chose "Euler" method!
Parameters are chosen to fit following measurements:
[1] Bauer C, Schröder E. Carbamino compounds of haemoglobin in human adult and foetal blood. The Journal of physiology 1972;227:457-71.
[2] Siggaard-Andersen O. Oxygen-Linked Hydrogen Ion Binding of Human Hemoglobin. Effects of Carbon Dioxide and 2, 3-Diphosphoglycerate I. Studies on Erythrolysate. Scandinavian Journal of Clinical & Laboratory Investigation 1971;27:351-60.
[3] Severinghaus JW. Simple, accurate equations for human blood O2 dissociation computations. Journal of Applied Physiology 1979;46:599-602.
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Real | pKzD | 7.73 | |
| Real | pKcD | 7.54 | |
| Real | pKhD | 7.52 | |
| Real | pKzO | 7.25 | |
| Real | pKcO | 8.35 | |
| Real | pKhO | 6.89 | |
| Physiolibrary.Types.MolarEnergy | dHzD | -51400 | |
| Physiolibrary.Types.MolarEnergy | dHzO | 7700 | |
| Physiolibrary.Types.MolarEnergy | dHcD | 59100 | |
| Physiolibrary.Types.MolarEnergy | dHcO | -41100 | |
| Physiolibrary.Types.MolarEnergy | dHhD | 49000 | |
| Physiolibrary.Types.MolarEnergy | dHhO | -105000 | |
| Physiolibrary.Types.MolarEnergy | dHo | 50000 | |
| Physiolibrary.Types.MolarEnergy | dH_HbuDANH2 | 0 | |
| Boolean | storeResults | false | |
| Boolean | loadStarts | true |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Physiolibrary.Types.RealIO.AmountOfSubstanceInput | tHb |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Physiolibrary.Chemical.Components.ChemicalReaction | K1 | ||
| Physiolibrary.Chemical.Components.ChemicalReaction | K2 | ||
| Physiolibrary.Chemical.Components.ChemicalReaction | K3 | ||
| Physiolibrary.Chemical.Components.ChemicalReaction | K4 | ||
| Physiolibrary.Chemical.Examples.Hemoglobin.Hemoglobin_MKM_Specie | Hb0 | ||
| Physiolibrary.Chemical.Examples.Hemoglobin.Hemoglobin_MKM_Specie | Hb1 | ||
| Physiolibrary.Chemical.Examples.Hemoglobin.Hemoglobin_MKM_Specie | Hb2 | ||
| Physiolibrary.Chemical.Examples.Hemoglobin.Hemoglobin_MKM_Specie | Hb3 | ||
| Physiolibrary.Chemical.Examples.Hemoglobin.Hemoglobin_MKM_Specie | Hb4 | ||
| Physiolibrary.SteadyStates.Components.MolarConservationLaw | totalHemoglobin | ||
| Physiolibrary.Chemical.Interfaces.ChemicalPort_a | O2 | ||
| Physiolibrary.Chemical.Interfaces.ChemicalPort_a | H3O | ||
| Physiolibrary.Chemical.Interfaces.ChemicalPort_a | CO2 |
Revisions
2014
Marek Matejak, Charles University, Prague, Czech Republic