modelCellularMetabolism

Diagram of CellularMetabolismOpen the diagram
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Extends from Physiolibrary.Icons.CellularMetabolism.

Parameters

TypeNameDefaultDescription
Physiolibrary.Types.DensityWaterDensity1000
BooleancanBurnFattyAcidstrue
Physiolibrary.Types.MolarEnergyglucoseEnergy(1/0.2439e-6)*4.1864*Substances.Glucose.mwMetabolism-Tools.CarboAerobic(mg/cal)=0.2439
Physiolibrary.Types.MolarEnergyfattyAcidsEnergy(1/0.1075e-6)*4.1864*Substances.FattyAcids.mwMetabolism-Tools.Fat(mg/cal)=0.1075
Physiolibrary.Types.MolarEnergylactateEnergy(1/0.2538e-6)*4.1864*Substances.Lactate.mwMetabolism-Tools.Lac-(mg/cal)=0.2438
Physiolibrary.Types.MolarEnergyketoAcidsEnergy(1/0.1075e-6)*4.1864*Substances.KetoAcids.mwMetabolism-Tools.Fat(mg/cal)=0.1075
Physiolibrary.Types.MolarEnergyoxygenEnergy(1/0.2093)*4.1864*22710.95322615
Physiolibrary.Types.MolarEnergyglucoseAnaerobicEnergyglucoseEnergy - lactateEnergy
Physiolibrary.Types.MolarEnergyglycogenAnaerobicEnergyglucoseAnaerobicEnergy
RealRQglu1how much CO2 will be produced with one oxygen by glucose burning
RealRQlac1how much CO2 will be produced with one oxygen by lactate burning
RealRQfat0.7how much CO2 will be produced with one oxygen by fatty acid burning
RealRQketo0.7how much CO2 will be produced with one oxygen by keto acid burning
RealLacFractionDatafraction of oxygen to be use for lactate metabolism (depends on lactate concentration)
RealPO2OnAerobicFractionData{{2, 0, 0}, {10, 1, 0}}Aerobic Fraction of O2 tissue use depents on pO2
Real[:,3]GlycogenAvailability{{0, 0.0, 0.0}, {50, 1.0, 0.0}}

Connectors

TypeNameDefaultDescription
Physiolibrary.Types.RealIO.MolarFlowRateOutputTissue_CO2FromMetabolism
Physiolibrary.Types.RealIO.VolumeFlowRateOutputTissue_MetabolicH2ORate
Physiolibrary.Types.RealIO.PowerInputCalsUse
Physiolibrary.Types.RealIO.PressureInputpO2
Physiolibrary.Types.RealIO.MolarFlowRateOutputO2Use

Components

TypeNameDefaultDescription
Physiolibrary.Blocks.Interpolation.CurveLacFraction
Physiolibrary.Chemical.Interfaces.ChemicalPort_alactate
Physiolibrary.Chemical.Interfaces.ChemicalPort_aglucose
Physiolibrary.Blocks.Interpolation.CurveAerobicFraction
Physiolibrary.Types.MolarFlowRateO2UseByGlu
Physiolibrary.Types.MolarFlowRateO2UseByLac
Physiolibrary.Types.MolarFlowRateO2UseByFA
Physiolibrary.Types.MolarFlowRateO2UseByKA
Physiolibrary.Types.FractionFAfraction
Physiolibrary.Types.FractionKAfraction
Physiolibrary.Types.FractionRatio
Physiolibrary.Types.PowerAnaerobicCals
Physiolibrary.Chemical.Interfaces.ChemicalPort_afattyAcids
Physiolibrary.Chemical.Interfaces.ChemicalPort_aglycogenglycogen flow
Physiolibrary.Blocks.Interpolation.CurveGlycogenAvailabilityCurve
Physiolibrary.Chemical.Interfaces.ChemicalPort_aketoAcids
Modelica.SIunits.PowergluWglucose.q*glucoseEnergy
Modelica.SIunits.PowergluO2WO2UseByGlu*oxygenEnergy
Modelica.SIunits.PowerlacWlactate.q*lactateEnergy
Modelica.SIunits.PowerlacO2WLacFraction.val*CalsUse
Modelica.SIunits.PoweranaerobicGluWglucoseAnaerobicEnergy*(glucose.q - (O2UseByGlu*oxygenEnergy)/glucoseEnergy)
Modelica.SIunits.PoweranaerobicGlyWglycogenAnaerobicEnergy*glycogen.q
Modelica.SIunits.MolarFlowRateanaerobicGluGly((glucose.q - (O2UseByGlu*oxygenEnergy)/glucoseEnergy) + glycogen.q)
Modelica.SIunits.MolarFlowRateanaerobicProducedLac(lactate.q - LacFraction.val*CalsUse/lactateEnergy)

Revisions

Author:

Marek Matejak

License:

Physiomodel License 1.0

Date of:

2012

References:

Tom Coleman: Physiomodel v1.5, University of Mississippi Medical Center

Copyright © 2014 Marek Matejak, Charles University in Prague.