.Physiomodel.Proteins

Information

Extracellular proteins determine the transfer of water between extracellular compartments such as plasma, tissue interstitia [Reed1993] or the glomerular filtration[Manning1987]. Proteins are also acid-base buffers, because side chains of some amino acids buffers the hydrogen ions [VanSlyke1928].

Plasma proteins: Albumin(66.5kDa) is about 60% of all prasma protein mass. It is synthetised and degraded in liver and distributed through the body [Beeken1962]. The rest of plasma proteins are mostly globulins. They are almost half-time smaller (about 34kDa), so their plasma molar concentration is higer than albumin in contrast with their plasma mass concentration. Both generate the osmotic pressure on capillary walls [Ahlqvist2003].

Problems:

hypoproteinanemia [Manning1983,1990]

hypogammaglobulinamia [Wollheim1964]

Contents

Name Description
 Synthesis
 Degradation
 ProteinsMass2AmountOfSubstance
 ProteinsMassConcentration2Concentration
 ProteinDivision 60% of total plasma protein mass are albumin
 Proteins
 IO_Bus

Revisions

Author:

Marek Matejak

License:

Physiomodel License 1.0

Date of:

2008-2015

References:

Tom Coleman: HumMod 1.6, University of Mississippi Medical Center

Copyright © 2008-2015 Marek Matejak, Charles University in Prague.


Generated at 2019-09-15T01:38:28Z by OpenModelicaOpenModelica 1.14.0~dev-26728-gbf603de using GenerateDoc.mos