.Physiomodel.Proteins .Physiomodel.ProteinsExtracellular proteins determine the transfer of water between extracellular compartments such as plasma, tissue interstitia [Reed1993] or the glomerular filtration[Manning1987]. Proteins are also acid-base buffers, because side chains of some amino acids buffers the hydrogen ions [VanSlyke1928].
Plasma proteins: Albumin(66.5kDa) is about 60% of all prasma protein mass. It is synthetised and degraded in liver and distributed through the body [Beeken1962]. The rest of plasma proteins are mostly globulins. They are almost half-time smaller (about 34kDa), so their plasma molar concentration is higer than albumin in contrast with their plasma mass concentration. Both generate the osmotic pressure on capillary walls [Ahlqvist2003].
Problems:
hypoproteinanemia [Manning1983,1990]
hypogammaglobulinamia [Wollheim1964]
| Name | Description |
|---|---|
 Synthesis | |
 Degradation | |
 ProteinsMass2AmountOfSubstance | |
 ProteinsMassConcentration2Concentration | |
 ProteinDivision | 60% of total plasma protein mass are albumin |
 Proteins | |
 IO_Bus |
Author: |
Marek Matejak |
License: |
|
Date of: |
2008-2015 |
References: |
Tom Coleman: HumMod 1.6, University of Mississippi Medical Center |
Copyright © 2008-2015 Marek Matejak, Charles University in Prague.