BE_interstitial is base excess in the interstitium of the tissue. The standard value is 0, when strong acid concentration increase, then BE value decrease with the same concentration.
Meaning might be interpreted like what amount of hydrogen iont must be added to sollution if the end poit of titration will be pH=7.4 and pCO2=5.3kPa.
For any tissue can be simplified with difference of lactate concentration from its normal value.
Marek Matejak, 24.12.2009