QHP 2008 / H2O Reference
There are several different ways to describe the body's
water compartments while implementing mass balance.
Water compartments can initially be divided into two
basic types: intracellular (ICFV) and extracellular (ECFV).
Intracellular compartments are red blood cells and
(all other) cells.
Extracellular compartments are plasma and interstitium.
Red Cells = 1.6
Cells = 26.4
-----
ICFV = 28.0
Interstitium = 12.0
Plasma = 3.0
-----
ECFV = 15.0
Total = 43.0
The problem with this scheme is that water cannot move
freely between plasma and interstitium but it can move
freely between interstitium and cell H2O.
So, we'll divide the body's water compartments into
vascular and extravascular. The vascular compartment
is futher subdivided into RBC water and plasma.
Red Cells = 1.6
Plasma = 3.0
---
Vascular = 4.6
Cells = 26.4 (ICFV less RBC's H2O)
Interstitium = 12.0
----
Extravascular = 38.4
Total = 43.0
To relax the nomenclature a bit, extravascular water
is referred to as tissue H2O.
This scheme is implemented using three integrals: plasma,
RBC and extravascular.
Exchanges are internal and external.
Internal exchanges are capillary
filtration and lymph flow.
External exchanges are many: absorption
from gut, urine, IV drip, transfusion,
hemorrhage ...
External exchanges influence the derivative
of either plasma or extravasular H2O.
Traditional compartments are also
represented here.
Red Cell H2O = 1584
Organ H2O = 26428
-----
Cell H2O = 28012
IFV = 11988
Plasma = 3000
-----
Extracellular = 14988
Total = 43000
-
- january 2009
by Marek Matejak in Modelica initially implemented (consulted with Jiri Kofranek), Charles University, Prague
orginaly described by Tom Coleman in QHP 2008 beta 3, University of Mississippi Medical Center
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